The only real hunting I have done with them has been using my daughters 6.5x55, and the 140gr. This rifle has enough freebore or leade that I can set one on top of the case and close the bolt with out touching anything.
This said they shoot like a dream from it and we have used it to take several deer and quite a few hogs, even at some ranges that surprised me. I only loaded them to around 2650fps due to her older 96 action and boy to they get-r-dun. Initially I was pretty reserved about them since Hornady had just released them when I tried them out. I contacted one of their tech's who had doubts about them on game but when I explained the rifle and the limited velocities, he figured about the same as I did that they would "probably" work, but he wouldn't go on record as recommending them.
Here is one of her deer she got about 10 years ago with one of them, two weeks before delivering my oldest grandson,
I have also loaded them in the 155gr weight for my .308 and a TC chambered in 30-30AI in which they both shoot great, but I have only taken a couple of hogs with the .308. They really put a smack down on them up close. But there again, I only loaded them with a mild load, since we're only shooting from a few feet to 75yds most of the time.