I have taken a deer with my Ruger Super Redhawk using .45 Colt ammo at about 40 yards. I have been able to shoot 4 inch groups at 100 yards with this gun and a 2x scope. I have a 50 yard zero and it drops 8 inches at 100. I am not confident with it past 100, as it will get into really steep part of the drop curve after that.
In the county where I hunt, centerfire rifle is not legal for deer. I just bought a T/C Encore in .308 Win. I haven't practiced enough with it yet to take it hunting, but my first session at the range gave me half inch wide groups at 50 yards, so it is promising for 150 to 200. Ammo tested was the Federal 150 grain SP Power-shok ammo. Still need a lot of practice with it.
Recoil is nowhere near as bad as expected. It does jump a bit, but great mass of the gun makes it less painful to shoot that a .454 Casull. I got the Pro Hunter package with the rubber grips.
I am setting up my reloading station for .308 and plan to use relatively inexpensive 150 gr FMJ bullets for practice. For 150 yards and greater I will need LOTS of practice with the pistol. While my groups are half inch wide at 50 yards, I am getting 2 inches of vertical stringing. No doubt because my grip and management of the recoil is not as consistent as it should be. LOTS of practice this spring, summer, and fall is indicated.
For hunting season I will re-zero my gun with Nosler partitions. Haven't decide on the 150s or the 165s yet. I have to see which is more accurate in my gun. All other things being equal I would be inclined to go with the 165s for the extra penetration.
My previous hunting experience has been with 300 grain .452 bullets either out of a revolver or a muzzleloader. But where I am hunting now, I need to hit at > 100 yards. Can't use a rifle. My shotgun isn't accurate enough. And I grow weary of all the paraphernalia needed for a muzzleloader. So I am going to try next year with the Encore in .308 Win. Should do the trick if I do my part. Practice, practice, practice.