The rimfire frames will only work with rimfire barrels, the firing pin is in the wrong location to work with centerfire chamberings even if the frames were meant for centerfire rifle pressures which they aren't, you'll need to find one of the rare 3 barrel combos to be able to use one of the offset bore rimfire barrels on it, they only made a few, so you'll have to be real lucky for that to happen. See the FAQs and Help sticky for base options. You'd be wise to ask about 22mag accuracy in the NEF Rimfire forum.
And Welcome aboard!!

Tim