Sounds interesting Gary, considering the 500S&W has an operating pressure of about 52kpsi and a case head of .526", the .513" head of the 350 Jacob should work fine as long as you keep the pressures at mid level, and hopefully since it's accurate at that starting load(which seems very low to me, I'm shooting 62gr RL15 in the Whelen with the 225gr TSX), it's got a great chance of being accurate at higher pressures. If you can PM me some specs, I can run it thru QL to see what you might achieve, need water weight capacity filled to overflow, bullet length and cartridge overall length.

Tim