I am a very fortunate man in the revolver category. I currently own 2 Dan Wesson 357's with multiple barrels(2.5",4".6".8"), 1 Dan Wesson 44mag with multiple barrels (4", 4"comp, 6", 6"factory hunter scope only, 8") and 2 Dan Wesson 445 Supermags with multiple barrels (4", 4" comp, 6" and 8"). As far as protection and hunting goes, I have the revolver end pretty well covered. If I could get only 1 other double action revolver, It would probably be a S&W 500 with a 4" tube. That would give a lot of extra power over my 445 Supermag for protection against rogue water buffalo, raging brown bears, and any carnivorous dinosaurs that may still be walking the planet.
Any dangerous animal too big for my 445 is really too big for any handgun, and I would rather have a long gun for protection aganst those beasts, but I would also rather have the extra power of the S&W 500 if it came down to "have to" with a handgun. If Dan Wesson came out with a 500 tomorrow, I would take a second mortgage if need be to buy one, and that would likely be the last revolver I would ever buy period, including extra barrels of course (except maybe a Ruger 9mm snubnose if I ever find a good used one.)