NY DRUG TRIALS: President Trump Sending Hydroxychloroquine and Zithromycin to NYC – t - Graybeard Outdoors
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post #1 of 9 (permalink) Old 03-22-2020, 01:54 PM Thread Starter
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Default NY DRUG TRIALS: President Trump Sending Hydroxychloroquine and Zithromycin to NYC – t


NY DRUG TRIALS: President Trump Sending Hydroxychloroquine and Zithromycin to NYC – the Epicenter of Coronavirus
By Pamela Geller - on March 22, 2020

A specific combination of existing drugs has shown it is capable of wiping out the #coronavirus in a study conducted in France. NY will start clinical drug trials on Tuesday for two newly approved drugs by the FDA including Chloroquine, which is used to treat malaria.

New York State will start trial testing antiviral medicines on Tuesday in an ongoing effort to stem the coronavirus pandemic statewide, Gov. Andrew M. Cuomo announced on Sunday.

70,000 Hydroxychloroquine –
10,000 Zithromax –
750,000 Chloroquine From the Federal Government.
Trials will start Tuesday.
President Trump is sending thousands of samples of the drugs hydrooxychloroquine, zithromax and chloroquine to New York for testing.

“We’re going to get this supply and the trial will start this Tuesday,” Cuomo said at his daily briefing on the pandemic in Albany. “[President Donald Trump] is optimistic about these drugs and we are all optimistic that it could work. I’ve spoken with a number of health officials and there is a good basis to believe that they could work.”

BREAKTHROUGH: 3 International Studies Find Chloroquine Show 100% SUCCESS Rate in Treating Coronavirus in 6 Days
Israeli drugmaker to DONATE 6 million doses of promising coronavirus drug hydroxychloroquine

Published Sun, Mar 22 2020:
The new state measures Cuomo announced include:

Army Corp of Engineers to construct four temporary hospitals in Stony Brook, Westchester, Westbury and the Javits Convention Center in Midtown Manhattan. The locations were chosen for various reasons including dormitory space for medical personnel
FEMA to construct four federal hospitals of 250 beds each
New York City to present a plan to reduce social interaction and density in parks and public spaces within 24 hours for the state to review
Hospitals must create plans to increase capacity by at least 50 percent, with a goal of 100 percent increase
All elective non-critical surgery will be canceled as of Wednesday
New York State will begin implementing trials of two drugs to treat COVID-19, the anti-malaria drug chloroquine and the antibiotic azithromycin on Tuesday.
Cuomo said that New York State currently has 53,000 hospital beds available. Projections estimate that as many as 110,000 beds could be needed as coronavirus cases peak.

Besides the multifold state response, Cuomo called on the federal government to nationalize the production of medical supplies needed for the pandemic.

“The states just can’t deal with finding the medical supplies they need.” Hospitals need these materials now, Cuomo urged.

Cuomo also asked the FDA to approve serological testing for antibodies to assess what percent of the population may have already been exposed to COVID-19.

As of Sunday morning, the total number of cases in New York reached 15,000. Here is how the current state statistics break down:

53 percent of cases are 18 to 49 years old
50,000 new tests were administered
4,800 new cases were confirmed
374 deaths to date have been recorded in New York State
70 percent of deaths so far were 70 years or older and the majority had underlying health conditions
80 percent of deaths under 70 years old had an underlying condition
1,900 patients have been hospitalized. The 13 percent hospitalization rate is lower than the previous rate of 15 percent.
These new mandates come after previous measures such as all non-essential employees being asked to stay at home and new rules concerning social distancing and “Matilda’s Law” for senior citizens and other vulnerable people.

Cuomo repeated pleas for residents to socially distance.

“You would think nothing was going on. There is a density level that is not appropriate and it has to stop now.”

Cuomo reassured residents that food and medication supply chains are not at risk of collapse.

“All essential services will be maintained”

“All that was great in the past was ridiculed, condemned, combated, suppressed — only to emerge all the more powerfully, all the more triumphantly from the struggle.”
― Nikola Tesla

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post #2 of 9 (permalink) Old 03-23-2020, 08:02 AM
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The lead to this post is misleading.

Having said that, it is a good thing that hydrooxychloroquine, zithromax and chloroquine have been sent to New York (and Washington) for testing in controlled clinical trials.

What is more important at the moment is to send PPE, especially n95 masks, to NY to protect doctors and nurses. And for New Yorkers to practice effective isolation....they weren't yesterday.

Chlolroquine does show some promise as a therapeutic (helps reduce symptoms and makes patients feel better, speed up recovery), but it does not prevent coronavirus from spreading and infecting new victims. And it needs to be tested to prove 1) causes no harm and 2) is really effective.
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post #3 of 9 (permalink) Old 03-23-2020, 08:53 AM
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You have to start somewhere, and NYC is as good a place as any
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post #4 of 9 (permalink) Old 03-23-2020, 12:55 PM
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These drugs have been around a long time, therefore the possible side effects and degree of safety is already known. Three international studies have shown them to be very effective for treating coronavirus. Sure, the studies involved a limited number of patients and they may not work as well in some people (the same as all drugs!).

So why delay their use on infected patients by conducting more "studies"?
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post #5 of 9 (permalink) Old 03-23-2020, 04:25 PM
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They actually have been and are being prescribed "off label" in some cases, at Physician discretion.

Trials to US standards are appropriate because the degree of safety for coronavirus victims has not been determined. Previous trials of these drugs demonstrated safety for malaria victims, but malaria is caused by a protozoan parasite and not by a virus. European trials being touted do not meet US FDA standards. Now, if FDA decided that relaxing US evaluation standards would be OK, that would be another matter. But FDA has not done that and is not likely to do so given
the "off label" option.

We should not forget the litigatious nature of some folks and the potential for medical malpractice lawsuits which has driven many medical protocol decisions which can gum up the works. A US MD prescribing anything off label better have his/her ducks in a row and very careful documentation that no other viable options were available....and certain that the off label prescription won't queer the malpractice insurance.

Everyone is hopeful that existing drugs will be shown to have therapeutic value, but they first have to be shown to cause no harm, then they have to be shown effective for coronavirus.

Last edited by M134 Troll; 03-23-2020 at 04:29 PM.
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post #6 of 9 (permalink) Old 03-23-2020, 07:48 PM
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One of the European trials reportedly had a cohort of only 20 people. 5 or 6 had undesirable outcomes. That does not inspire confidence in conclusions drawn from such a drug trial.
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post #7 of 9 (permalink) Old 03-24-2020, 10:07 AM
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5 or 6 undesirable outcome? This one has not been on any thing I have watched or listened to. So I guess it is good that NY is going to see if it is true. The Chinese have been using this, they noticed that people with Lupis did not catch the Corona V. They use this same drug. It should be a pretty safe drug to try as it has been around for many years.
But because Trump likes it every one else is against it (TDS). I noticed the Dr who kind of popoed Trump on tv over his wanting to try the drug combo has been missing the last couple press conferences. Must be on time out!
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post #8 of 9 (permalink) Old 03-25-2020, 11:50 AM
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Hydroxychloroquine also halts the cytokine storm which is the real cause of phlegm blocked lungs with CV infection.

It is interesting to note Dem govenors of Michigan and Nevada have outlawed use of hydroxychloroquine in CV cases; which in my opinion is beyond criminal . Also interesting to note majority of world's hydroxychloroquine supply comes from Russia...the Teva Pharma factory built by Israelis a few years ago

So M123Troll....I assume if you were laying in bed gasping for oxygen with endstage Covid disease, you would refuse hydroxychloroquine and Z-tab therapy. Do I have that correct, at least until whenever the FDA concludes their protocol studies?
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post #9 of 9 (permalink) Old 03-25-2020, 01:02 PM
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Double checked the European trial: 26 cohorts, 6 undesirable outcomes including one death. One person quit the trial so there were 5 undesirable clinical outcomes IIRC.

Yes, Hydroxychloroquine helps dampen the cytokine storm kicked out by over-reacting immune systems. Apparently not all patients can tolerate it but I certainly would not refuse it in extremis.

Michigan patients already prescribed Hydroxychloroquine for labeled diseases cannot get their scrips filled because of a run on the drug by the "worried well" and hoarders....aided by physicians writing "off label" scrips for undiagnosed people. When that gets sorted out and NY and Washington trials are completed with positive results I expect whatever prohibition was put in place would be lifted.
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