I had two single six convertables for a while and it didn't matter which cylinder out of the 4 of them you put in either of the two guns. I also have a 44 mag super Blackhawk and picked up a 4440 cylinder for it and it dropped right in and worked fine. Rugers are hardly precisely made guns and I doubt theres a single bit of hand fitting at the factory.
I am thinking you would have to send your pistol to the factory as a cylinder would have to be fitted and timed
MAKE AMERICA GREAT AGAIN! STEEL FOR TANKS NOT FENCES!!!