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I have had the same thought, and even trying them in my .222 Rem. I'm currently shooting Nosler 40 gr. BT in both my .223 Contender and my 788 in .222.
A shooting partner of mine tried them in his 22-250 or his 22BR I can't remember which on though. He said they shot alright but I know he didn't switch over to them.
I will have to get a handful and try them at 222 and 223 velocities and see what happens. I guess there is some kind of data in the latest Hornady book.
If I ever try it, I will post the info.
Stan
 
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