Mud dude, I don't have a .25-06 handi, but I do have a .25-06. I love the hornady 117gr. SST ammo, and 100gr. rem. Just try some and see what your gun likes to eat best. For me Federal 117 btsp ammo is awful, 3" and 4" groups from a sub 1/4" shooter. So just play around with it. Hornady is pretty inexpensive for premium grade factory ammo too!