Both are pretty popular. I think quite a few bear guides use the 375. The 375 can be a pretty good all 'round gun for Alaska though its a bit heavy for some critters. Good bear and moose medicine. I'd prefer the 375 over the 45-70 myself.
The 375 H&H is much more versitile, and it is a fairly popular round. The three most popular hunting rounds are the 30-06, 300 win mag and 338 win mag. The curve tapers off sharply in both directions of folks preferring smaller or larger rounds.
The vast majority of bear guides use a 375 H&H or larger. It is an outstanding round for moose as well.
As was mentioned both are popular up here. I just got rid of my 375. I'll keep my 45/70 and use my 338 as my primary rifle. If I had to pick between the 2, I would pick the 375. Since I hunt and hike in thicker woods area, I chose the 45/70 over the 375.
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