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I've always used Winchester Large Pistol primers in the 45 Colt, wether it's a 270gr @ 800 fps or a [email protected] 1,300 fps. I haven't had any problems using H110, WLP primers and 310gr LFN bullets from Leadhead's.

In a Ruger 21.5gr of H110 under a 310gr LFN is a good starting point, that load does right around 1,050 fps from my 7.5" Blackhawk.
 

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Yep, always use the Win "std and mag", or other magnum primer with H110. Especially in cold weather.
 
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