It is weird how different is different....
I usually sight my rifles for the use. I have different loads for different things, and they shoot different. There are some bullets that will shoot with a 2" variation in the windage from the others, while still holding good groups, not just the elevation differs, so I have to adapt. (Well, actually only one, which I think I'm going to stop using...) Each time I go out for a hunt, I have to know the load I'm using, and make sure I am shooting accordingly.
When I'm out and have 180 grain TSX's with me for moose, and also 130 grain JSP's with me for wolf, there is a big difference between them, so I have to shoot them both and get to know them both so I can switch on and off.